Gunners boss Arsene Wenger has rewarded the Frenchman for his brace from the bench against Sunderland with a start in Sofia
Olivier Giroud will make his first start of the season for Arsenal against Ludogorets in the Champions League on Tuesday night.
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Aaron Ramsey makes only his second start of the campaign in all competitions after an injury, while Carl Jenkinson returns to the first-team fold at right-back.
Giroud scored twice from the bench in Arsenal’s 4-1 win at Sunderland on Saturday and he replaces Alex Iwobi, who drops to the bench, with Alexis Sanchez expected to move from centre-forward to the left-wing.
David Ospina continues as Arsenal’s Champions League goalkeeper, replacing Petr Chech, while Granit Xhaka returns in midfield after suspension.
Hector Bellerin, Theo Walcott and Nacho Monreal have not travelled to Bulgaria, but boss Arsene Wenger was coy on their chances of facing Tottenham on Sunday.
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Arsenal: Ospina; Jenkinson, Mustafi, Koscielny, Gibbs; Coquelin, Xhaka; Ramsey, Ozil, Alexis; Giroud.
Subs: Cech, Gabriel, Holding, Elneny, Maitland-Niles, Oxlade-Chamberlain, Iwobi.